INTRODUCTION TO NANOMATERIALS AND NANOBIOMATERIALS:
History of Nanotechnology and Nanobiotechnology, scope and Applications. Structures and properties of Carbon based, metal based andbionanomaterails: Fullerenes, Bucky Ball, Nanotubes, Quantum Dots, Magnetic, Nano Shells,Dendrimers, Nanocarriers, Nanocrystals, Nanowires, Nanomembranes, hybrid biological/inorganic, protein & DNA based nanostructures. Introduction & overview of 1st, 2nd and 3rd generation biomaterials.
CHARACTERIZATION OF NANOSTRUCTURES:
UV-Visible spectroscopy, Electron Microscopy-Scanning electron microscopy (SEM), Atomic Force microscopy (AFM), Transmission electron microscopy (TEM), Scanning Probe microscopy (SPM), Scanning tunnel microscopy (STM); Fourier Transform infrared spectroscopy (FTIR); X-ray spectroscopy
NANO SYNTHESIS AND FABRICATION:
Introduction & overview of Nanofabrication: Bottom up-self-assembly and Top down approaches using processes like Ball milling, Sol-gel Process, Chemical Vapor deposition (CVD). Plasma or flame spraying synthesis, Ion-Bean sculpting electrodeposition and various lithography techniques. Nanolithography and Soft lithography. Biosensors: types, applications and developments. Biosensor in modern medicine.
APPLICATION OF NANOBIOTECHNOLOGY:
Medical Nanobiotechnology: Diagnostics: Imaging: Benefits and Applications. Nanotherapeutics: cancer treatment – Nanotechnology based chemotherapy (Smart Bomb), Pebbles, wound care products, Implantable materials for vascular interventions, Implantables materials for orthopaedics and dentistry. Active implantable devices and biomics. Nanosurgery. Pharmaceutical Nanobiotechnology: Drug delivery – Nanoparticles used as drug delivery systems, types of drug loading, drug release (sustained and targeted release mechanism), Biodegradable polymers. Application in the field of Nano Surgery and Tissue Engineering. Nano Safety Issues: Nanotoxicology: Toxicology health effects caused by Nanoparticles, EthicsChallenges and Future.
BIOMEMS AND NEMS:
Micro & Nano-Electromechanical systems – Fabrication process – choice of materials – advantages and limits of various approaches, Applications, Thermal Radiations, Magnetic, Chemical and Mechanical Transducers – Sensing and Actuators.
Course outcomes:
After studying this course, students will be able to:
• Demonstrate strong basics in principles of Nanotechnology
• Tackle live problems in Nanobiotechnology
• Conceptualize the design and development aspects in the domains like NEMS/BIOMEMS
Question paper pattern:
The SEE question paper will be set for 100 marks and the marks scored will be proportionately reduced to 60.
• The question paper will have ten full questions carrying equal marks.
• Each full question is for 20 marks.
• There will be two full questions (with a maximum of four sub questions) from each module.
• Each full question will have sub question covering all the topics under a module.
• The students will have to answer five full questions, selecting one full question from each module.
Textbooks
1 Nanotechnology in biology and Medicine Tuan Vo-Dine, Tylor and Francis CRC 2009
2 Introduction to NanoScience and nanotechnology Poole C P and Owens F J Wiley 2004
Reference Books
1 Nanotechnology Greggory Timp Springer 1999
2 Nanotechnology Nanotechnology IK international publication 2008
3 Biological Molecules in Nanotechnology Stephen lee and Lynn M Savage International Business Communications