Immunopathology:
Tolerance and Autoimmunity, Hypersensitive reactions, Primary and Secondary Immunodeficiency, Active and passive immunization, General immunization practices, , AIDS, Immune response to Infectious disease, Basic principles of vaccine development. Vaccination of immune-compromised hosts, Vaccination of human immunodeficiency virus- infected persons. Vaccines and its historical perspective.
Traditional and modern methods of vaccine production, Egg and cell based vaccine development, Current and future scenario of Vaccines, Edible Vaccines, Reverse vaccinology, Immunoinformatics approach to identify T and B cell epitopes, Bacterial and Viral vaccine. Passive immunization; antibody, transfusion of immune competent cells, cell based vaccines. Immunomodulators (cytokines) Innovative methods of delivery of immunogens through liposomes, microspheres, ISCOMS.
Vaccine Technology:
Criteria for effective vaccine, Vaccines, Live, killed, attenuated, sub unit vaccines; Role and properties of adjuvants, recombinant DNA and protein based vaccines, Multivalent subunit vaccines, mini cell vaccines, conjugate vaccines plant-based vaccines, recombinant antigens as vaccines. Interferons, designing and screening for antivirals, mechanisms of action, antiviral libraries, antiretrovirals— mechanism of action and drug resistance. Comparative Genomics as a tool for vaccine design
Licensed vaccines, Viral Vaccine (Poliovirus vaccine-inactivated & Live, Rabies vaccines Hepatitis A & B vaccines), Bacterial Vaccine (Anthrax vaccines, Cholera vaccines, Diphtheria toxoid), Parasitic vaccine (Malaria Vaccine). Vaccines against Hepatitis A, Malaria, Typhoid (in clinical trials). Conventional vaccines, antiidiotype vaccine, naked DNA vaccine. Recombinant Vaccines - Definition, recombinant vector vaccines, DNA vaccines. Vaccine potency testing.