INTRODUCTION TO BIOCHIP AND MICROARRAY CONSTRUCTION:
Basics of Biochips and Microarray Technology, Biochip technologies. Types of Biochips - DNA Microarrays, Oligonucleotide, cDNA and genomic microarrays, Integrated biochip system. Biochip versus gelbased methods. Limitations of biochip technology
BIOCHIP CONSTRUCTION :
Megacne technology for fluid microarrays, Microarray labels, Microarray scanners, Microarray robotics. Microfluidics systems, Chips and Mass Spectrometry. Electrical detection methods for microarrays
APPLICATIONS OF BIOCHIPS:
Tissue Chip, RNA Chip, Protein Chip Technology, Glycochips, Biochip assays, Combination of microarray and biosensor technology.Microarray Data analysis: Introduction, Image Acquisition and Analysis, Detection of differential gene expression. Pathway analysis tools. Data validation.
GENOMIC SIGNAL PROCESSING:
Introduction, Mathematical models, and Modeling DNA Microarray data - Singular Value Decomposition algorithm. Online Analysis of Microarray Data Using Artificial Neural Networks
DNA COMPUTING:
Introduction, Junctions, other shapes, Biochips and largescale structures. Strand algebras for DNA computing – Introduction, Strand Algebras. Discussion of Robinson and Kallenbach's methods for designing DNA shapes, DNA cube, computing with DNA, Electrical analogies for biological circuits, Challenges, Future Trends. Discussions with case studies