INTRODUCTION TO BIOREACTORS:
Overview of biological reactors: submerged liquid fermentation, solid state fermentation,
Understanding of bioreactors:
Definition of bioreactor, development of bioreactors, Purpose and importance of bioreactor, Classification of bioreactors, bioreactor for animal cell, plant cell cultivation/culture.
TRANSPORT PHENOMENA IN BIOPROCESS SYSTEMS:
Gas liquid mass transfer in Cellular Systems. Determination of O2 transfers rates. Mass transfer of freely rising or falling bodies.
Forced Convection Mass Transfer:
Overall Kla Estimates, and power requirements (review) for sparged and agitated vessels. Other factors affecting Kla, Models, Power Consumption and Mass transfer for Non Newtonian fluids.
BIOREACTOR OPERATIONS:
Common operations of bioreactor, selection and identifications of factors for smooth operations of bioreactors, spectrum of basic bioreactor operations, bioreactor operations for immobilizes systems, plant and animal cell bioreactors operation
CONTROLS IN BIOREACTORS
Control task in bioreactor system, instrumentation in bioreactors, control variables and measurement devices, advanced control technique, consistency checks on measurement, adaptive online optimizations. Online and off line measurements and analytical methods.
STERLISATION AND SCALE UP OF BIOREACTORS:
Sterilization of Reactors, Batch Sterilization, Continuous Sterilization, filter and air sterilization. Scale up problems in bioreactors, criteria of scale up, similarity criteria; scale up methods, generalized approaches to scale up.