18BT35 Cell Biology and Genetics syllabus for BT

CYTOSKELETON:

Eukaryotic and prokaryotic cells, Plant and animal cells, brief mention of membrane organization. Cytosketal elements, Microtubules: structure & functions, shaping of the cells and mechanical support. Microfilaments: structure & functions. Structure of intermediate filaments. Cytoplasmic micro trabecular system (lattice). Covalent modifications of cytosketal proteins. Cytoskeletal architecture.

CELL STRUCTURE AND FUNCTION:

Mitosis and Meiosis. Structure of cytoplasm, Nucleus, Mitochondria, Ribosome, Golgi bodies, Lysosomes. Endoplasmic Reticulum, Peroxisomes, Chloroplast and Vacuoles. Cell to cell integration, Cell locomotion (Amoeboid, Flagella, Cillar).Types of cell functions, cell division. Apoptosis and Ageing

GENETICS:

Nature of genetic material, Mendelian Laws of inheritance, monohybrid and dihybrid inheritance, law of segregation & independent assortment, Gene interactions, supplementary genes - Comb patterns in fowls, Complementary genes - Flower color in sweet peas, Epistasis- Inhibitory and colored genes in fowls, simple problems. Identification of genetic material, classical experiments- Hershey & Chase, Avery, McLeod etc., Multiple alleles and groups antigens. Numericals based on concepts.

CHROMOSOMES STRUCTURE AND ORGANIZATION & POPULATION GENETICS:

Chromosome, Centrosome, telomere, Chemical composition of chromatin, structural organization of nucleosomes, heterochromatin. Polytene and lamp-brush chromosomes, human chromosomes. Introduction, Gene frequency, and equilibrium estimation, changes in gene frequency, inbreeding and heterosis, genetic structure of population, speciation and evolution, prospects for the control of human evolution. Spontaneous and induced mutations, Eugenics. Pedigree analysis.

SEX CHROMOSOMES AND INHERITED DISEASES:

The organ of heredity, chromosomes, morphology, classification. Sex determination in plants, animals XX-XY, XX-XO, ZW-ZZ, ZO-ZZ types in animals. Chromosomal disorders. Sex linked inheritance molecular diseases, hemoglobinpathies. Disorders of coagulation, Color blindness, hemophilia, Non-disjunction as a proof of chromosomal theory of inheritance, Linkage maps, crossing over. Chromosomal maps, interference coincidence.

Course Outcomes:

At the end of the course the student will be able to:

• Comprehend the basics of cell biology & genetics
• Understand the basis of inherited disorders.

Question paper pattern:

• The question paper will have ten full questions carrying equal marks.
• Each full question will be for 20 marks.
• There will be two full questions (with a maximum of four sub- questions) from each module.
• Each full question will have sub- question covering all the topics under a module.
• The students will have to answer five full questions, selecting one full question from each module.

Textbook/s

1 Cell Biology S C Rastogi New Age International Pub 2011. 3rd Edition

2 Cell Biology Kimbal Willey Pub 3rd Edition

3 Genetics W Strick, Monroe Macmillan Publication 1968

Reference Books

1 Molecular Cell Biology Darnell, and Baltimore Freeman Pub 2nd Edition 1993

2 Cellular & Biochemical Science G. Tripathi I K Intl 2010

3 Principles of Genetics Gardener, Simmons and Slustad Wiley Pub 8 Edition