18BT52 Chemical Reaction Engineering syllabus for BT

INTRODUCTION Law of mass action and rate equation, definitions and examples of elementary and nonelementary reactions, theories of reaction rate and temperature dependency, analysis of experimental reactor data - evaluation of rate equation by integral and differential analysis for constant volume system . Conceptual numericals.

BIOREACTORS Design equations for homogeneous system - batch, stirred tank and tubular flow reactor, size comparison of single reactors, combination of reactor systems - Qualitative design for parallel and series reactors. Conceptual numerical

NON-IDEAL BIOREACTORS

Non-ideal reactors, residence time distribution studies for pulse and step input, Exit age distribution of fluid in reactors, RTD’s for CSTR and PFR, calculations of conversions for First order reactions. Conceptual numerical.

ENZYME KINETICS

Enzyme active site, types of enzyme specificities, enzyme kinetics, initial velocity studies, formation of ES complex, derivation of Michaelis-Menton equation, definition of Km and Vmax, Lineweaver-Burk and Eadie-Hofstee plots. Units of enzyme activity, Enzyme inhibition: competitive, uncompetitive and non-competitive. Conceptual numerical

KINETICS OF MICROBIAL GROWTH AND MEDIA DESIGN

Monod model; Growth of Filamentous Organisms. Growth associated (primary) and nongrowth associated (secondary) product formation kinetics; Leudeking-Piret models; substrate and product inhibition on cell growth and product formation; Conceptual numericals. Medium requirements for fermentation processes- Carbon, nitrogen, minerals, vitamins and other complex nutrients; oxygen requirements; Medium formulation for optimal growth.

Course outcomes:

At the end of the course the student will be able to:

• Understand the mechanism and kinetics of chemical , enzyme and microbial reactions.
• Identify and summarize the parameters from range reactions to optimize reactor design and development.
• Demonstrate the use of various scientific parameters to improve the performance of fermentation process
• Develop suitable environment for microbial growth by analysing various parameters.

Question paper pattern:

• The question paper will have ten full questions carrying equal marks.
• Each full question will be for 20 marks.
• There will be two full questions (with a maximum of four sub- questions) from each module.
• Each full question will have sub- question covering all the topics under a module.
• The students will have to answer five full questions, selecting one full question from each module.

Textbook/s

1 Chemical Reaction Engineering Levenspiel O John Wiley 3rd Edition 1998

2 Elements of Chemical Reaction Engineering Fogler, H.S Prentice Hall 3rd Edition 2004

3 Bioprocess Engineering: Basic Concepts Fikret Kargi, Matthew DeLisa, and Michael L. Shuler Prentice Hall Third Edition 2017

4 Enzyme Kinetics and Mechanism Paul F Cook & W W Cleland Garland Science 2007

Reference Books

1 Bioenergetics David Nicholls Academic Press 4th Edition 2013

2 Chemical Reactor Analysis and Design Forment G F and Bischoff K B John Wiley 3rd Edition 2010